Should my child have their cholesterol level checked?
The answer is yes, especially if heart disease runs in your family
Lisa Khalafi of Bedford was 16 when her mother, Jane, 39, had a heart attack and bypass surgery. Even though Jane’s mother died of a heart attack at age 43 and her maternal grandmother died at 39, it never occurred to Jane she might be at risk. She wasn’t overweight, she didn’t smoke, her blood pressure was normal and she didn’t have diabetes. What Jane did not know was that her cholesterol put her at risk.
Jane’s LDL-Cholesterol (LDL-C) was over 350 milligrams per deciliter (mg/dL) at the time of her heart attack (LDL stands for low-density lipoproteins and is sometimes called the ‘bad’ cholesterol). Normal LDL-C is less than 100 mg/dL and it should be less than 70 mg/dL in people with heart disease.
Even though she was treated with cholesterol-lowering medications, it wasn’t until I met Jane five years later that she learned her diagnosis — familial hypercholesterolemia — which is a common genetic disorder. Lisa inherited the familial hypercholesterolemia gene and so have three of Lisa’s four children.
Familial hypercholesterolemia affects one in every 250 people worldwide and should be suspected in adults with an untreated LDL-C greater than 190 mg/dL and in children with an LDL-C over 160 mg/dL. Some populations, including French-Canadians, are at higher risk. Each time a person with familial hypercholesterolemia has a child there is a 50 percent chance of that gene being passed on. Diet is not sufficient to normalize cholesterol levels; everyone with familial hypercholesterolemia requires medication.
Lisa, now 47, has been on cholesterol-lowering medications since her 20s and has never had a cardiac event. Her children have been treated since they were 10 years old. The American Academy of Pediatrics and the American Heart Association recommend that children from families with premature heart disease have a cholesterol profile at age 2 and that all children be screened between the ages of 9 and 11 and again between ages 17 and 21.
Children suspected of having familial hypercholesterolemia should be treated with both a low-fat diet and cholesterol-lowering medications starting at age 10. Studies have shown that by this age children with familial hypercholesterolemia begin depositing cholesterol in their heart and other arteries. Individuals treated when they were children had far fewer heart attacks and deaths from heart disease as adults compared to their parents who were not treated until later in life.
If you have a family history of heart disease, ask your health care provider to screen your children at age 2. If you do not have a family history of heart disease, have your children’s cholesterol tested between the ages of nine and 11.
Mary McGowan, MD, is the co-director of the Lipid Clinic at Dartmouth-Hitchcock Heart & Vascular Center, and is an assistant professor of medicine at The Geisel School of Medicine.